"Paleolithic nutrition improves plasma lipid concentrations of hypercholesterolemic adults to a greater extent than traditional heart-healthy dietary recommendations"

New research provides evidence in support of "Paleo Diet" for heart health.  N = 20.

Direct quotes from Article in Press

The 2010 Dietary Guidelines for American and current American Heart Association (AHA) general recommendations for the dietary management of hypercholesterolemia are to limit dietary saturated fat, with most energy intake derived from carbohydrate, in a calorically appropriate diet for the individual [3-5]. There is evidence, however, that such a macronutrient shift may result in increased atherosclerotic risk, with reduced high-density lipoprotein (HDL) and an elevation in C-reactive protein, triacylglycerols (TG), very low-density lipoprotein, small DLD, and oxidized LDL [6-11].
The diet has received criticism, particularly over the potential for increased atherogenic risk due to higher fat and meat intakes [24]. When compared to a typical American/Western diet, however, a Paleolithic diet contains 3-fold more fiber and potassium, 2-fold more polyunsatured and monounsatured fats, 4-fold more omega-3 fatty acids and 4-fold less sodium [25-27].
Relative to traditional diabetic and Mediterranean diets, a Paleolithic diet is more satiating per calorie consumed [19, 20]. This effect can lead to an overall lower energy intake in the absence of defined energy restrictions [12].